TP73-AS2

Across TCGA pan-cancer cohorts, TP73-AS2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TP73-AS2 data layer.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher TP73-AS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TP73-AS2 expression acts as an unfavorable survival marker, although some lineages such as LAML and UCS show a favorable association.

CHOL, ESCA, and LIHC are the cancer types where TP73-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	All	0.024	0.675	<.001	81	view →
ESCA	OS	Quartile	All	0.428	0.735	<.001	71	view →
LIHC	DFS	Tertile	II,III,IV	0.184	0.449	<.001	48	view →
MESO	OS	Tertile	III,IV	0.287	0.604	.003	36	view →
LUSC	OS	Tertile	IV	0.057	0.786	.008	36	view →
LAML	DFS	Median	All	0.552	0.365	.007	30	view →
ACC	OS	Tertile	All	0.571	0.913	.001	27	view →
UCS	DFS	Median	IV	0.981	0.450	.004	18	view →
UCEC	DFS	Tertile	IV	0.196	0.533	.042	18	view →
THCA	DFS	Tertile	IV	0.401	0.710	.025	18	view →
LUAD	DFS	Tertile	IV	0.140	0.603	.021	18	view →
READ	DFS	Tertile	All	1.000	0.737	.021	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TP73-AS2–CHOL (OS)

Open the CHOL breakdown →