TP73-AS2

Across TCGA pan-cancer cohorts, TP73-AS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TP73-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TP73-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types TP73-AS2 is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

THCA, ESCA, and LUSC are the cancer types where TP73-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TP73-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.064	.022	3	view →
ESCA	All	II,III,IV	+0.220	.031	2	view →
LUSC	Female	All	+0.192	.012	2	view →
LUAD	All	All	+0.134	.010	2	view →
STAD	Male	II,III,IV	+0.130	.042	2	view →
UCEC	All	All	+0.105	.018	2	view →
HNSC	Male	IV	−0.060	.027	2	view →
KIRC	All	All	+0.023	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TP73-AS2–THCA

Open the THCA breakdown →