TP63

Across TCGA pan-cancer cohorts, TP63 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TP63 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TP63 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TP63 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

COAD, UCEC, and LIHC are the cancer types where TP63 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.568	0.877	.007	21	view →
UCEC	DFS	Median	All	0.905	0.583	.005	18	view →
LIHC	OS	Median	III,IV	0.051	0.650	<.001	12	view →
STAD	DFS	Median	III,IV	1.000	0.333	.020	11	view →
SARC	OS	Median	All	0.307	0.733	.022	6	view →
PRAD	DFS	Median	All	0.617	0.886	.027	6	view →
ESCA	DFS	Median	III,IV	0.023	0.443	<.001	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →
KICH	DFS	Median	II,III,IV	0.102	0.775	.025	3	view →
READ	OS	Median	All	0.281	0.830	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TP63–COAD (OS)

Open the COAD breakdown →