TP63

Across TCGA pan-cancer cohorts, TP63 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TP63’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TP63 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TP63 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

HNSC, LUSC, and UCEC are the cancer types where TP63 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TP63 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.057	<.001	12	view →
LUSC	Female	II,III,IV	+4.902	<.001	8	view →
UCEC	All	III,IV	+0.256	<.001	8	view →
KIRC	Male	II,III,IV	−0.154	.004	7	view →
BRCA	Female	All	−2.467	<.001	6	view →
KIRP	Male	All	−0.334	<.001	6	view →
LIHC	Male	All	+0.281	<.001	5	view →
BLCA	All	All	+1.776	.030	3	view →
THCA	All	All	+0.612	<.001	3	view →
PRAD	All	All	−1.627	<.001	2	view →
READ	Female	All	−0.356	.049	1	view →
CHOL	All	All	+0.202	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TP63–HNSC

Open the HNSC breakdown →