TP63

Across TCGA patient cohorts, TP63 mutation is significantly associated with the RNA expression of many other genes, with 5,689 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP63-associated genes across cancer lineages are CENPM, EMC9, and UQCRH. Each is linked with TP63 in more than 3 cancer types. Because this analysis shows association rather than direction, both TP63-to-partner and partner-to-TP63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by TP63-low versus TP63-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP63→partner) and Y-score (partner→TP63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPM →	+0.658	+3.595	.003	.001	3	4
COAD	EMC9 →	+0.490	+3.486	.005	.002	3	4
UCEC	UQCRH →	+0.667	+2.147	<.001	<.001	3	4
HNSC	SMIM4 →	+0.900	+3.356	<.001	.005	3	4
HNSC	MRPL57 →	+0.500	+3.356	.001	.005	3	4
SKCM	LTBP2 →	-0.490	-1.154	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,689 associations by consensus.

CENPM by TP63 expression — COAD

Explore this box plot interactively →