TP63

Across TCGA cell cohorts, TP63 mutation is significantly associated with the RNA expression of many other genes, with 244 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TP63-associated genes across cancer lineages are POLR3B, ZCRB1, and YAF2. Each is linked with TP63 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP63-to-partner and partner-to-TP63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR3B grouped by TP63-low versus TP63-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP63→partner) and Y-score (partner→TP63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	POLR3B →	+0.700	+3.199	.001	.007	3	2
BLOOD_Leukemia	ZCRB1 →	+0.460	+3.259	.007	.006	3	2
BLOOD_Leukemia	YAF2 →	+0.492	+3.199	.001	.007	3	2
BLOOD_Leukemia	TCEAL6 →	+0.021	+3.356	.003	<.001	3	2
BLOOD_Leukemia	LY6G6F →	+0.886	+2.900	<.001	.001	3	2
BLOOD_Leukemia	ZBTB9 →	+0.557	+3.199	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 244 associations by consensus.

POLR3B by TP63 expression — BLOOD_Leukemia

Explore this box plot interactively →