TP53TG5

Across TCGA patient cohorts, TP53TG5 mutation is significantly associated with the RNA expression of many other genes, with 325 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53TG5-associated genes across cancer lineages are OR10H3, RNU6-151P, and RNU6-1067P. Each is linked with TP53TG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53TG5-to-partner and partner-to-TP53TG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10H3 grouped by TP53TG5-low versus TP53TG5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53TG5→partner) and Y-score (partner→TP53TG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR10H3 →	+0.164	+5.148	<.001	.002	3	2
SKCM	RNU6-151P →	+0.222	+3.010	.006	.006	3	2
SKCM	RNU6-1067P →	+0.303	+2.915	.002	.008	3	2
LUSC	PRAMEF1 →	+0.094	+4.417	.002	.002	3	2
LUSC	RNU6-338P →	+0.280	+4.606	<.001	.006	3	2
LUSC	RN7SL503P →	+0.193	+3.684	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 325 associations by consensus.

OR10H3 by TP53TG5 expression — LUSC

Explore this box plot interactively →