TP53TG5

Across TCGA pan-cancer cohorts, TP53TG5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TP53TG5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TP53TG5 RNA is repressed in tumor relative to normal tissue. In most cancer types TP53TG5 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where TP53TG5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TP53TG5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.560	<.001	9	view →
HNSC	All	All	+0.145	.001	8	view →
LIHC	All	II,III,IV	+0.154	<.001	7	view →
KICH	All	All	−0.232	<.001	4	view →
CHOL	All	All	+0.753	<.001	3	view →
READ	All	III,IV	+0.404	.013	2	view →
BLCA	All	IV	−0.375	.037	2	view →
UCEC	All	All	−0.350	.001	2	view →
COAD	All	All	+0.157	.019	2	view →
STAD	All	II,III,IV	+0.241	.037	1	view →
LUAD	Female	II,III,IV	−0.221	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TP53TG5–THCA

Open the THCA breakdown →