TP53RK

Across TCGA pan-cancer cohorts, TP53RK RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated TP53RK data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TP53RK RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TP53RK expression acts as an unfavorable survival marker, although some lineages such as READ and MESO show a favorable association.

UVM, LIHC, and UCEC are the cancer types where TP53RK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.438	0.735	.001	104	view →
LIHC	OS	Median	All	0.605	0.762	<.001	97	view →
UCEC	DFS	Median	All	0.780	0.890	<.001	52	view →
DLBC	DFS	Median	II,III,IV	0.168	1.000	<.001	38	view →
PAAD	DFS	Tertile	All	0.332	0.640	.001	21	view →
LGG	OS	Tertile	All	0.727	0.937	<.001	20	view →
READ	OS	Quartile	III,IV	0.911	0.284	.006	20	view →
CESC	OS	Median	IV	0.106	0.594	.021	14	view →
TGCT	DFS	Median	All	0.765	0.900	.009	14	view →
MESO	DFS	Quartile	II,III,IV	0.783	0.308	.006	12	view →
THYM	OS	Tertile	All	1.000	0.665	.006	12	view →
PRAD	DFS	Quartile	All	0.938	0.820	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

TP53RK–UVM (DFS)

Open the UVM breakdown →