TP53RK

Across TCGA pan-cancer cohorts, TP53RK RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TP53RK’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TP53RK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TP53RK is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where TP53RK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TP53RK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.254	<.001	11	view →
LIHC	Male	II,III,IV	+1.090	<.001	9	view →
HNSC	Male	III,IV	+0.645	<.001	8	view →
READ	All	All	+1.036	<.001	7	view →
STAD	All	II,III,IV	+0.842	<.001	6	view →
BRCA	All	III,IV	+0.643	<.001	6	view →
CHOL	Male	All	+1.691	<.001	5	view →
KICH	Female	All	−0.620	<.001	5	view →
ESCA	All	II,III,IV	+0.809	.002	4	view →
BLCA	All	IV	+0.410	.039	2	view →
PRAD	All	All	+0.239	.023	2	view →
THCA	All	IV	−0.517	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TP53RK–COAD

Open the COAD breakdown →