TP53RK

Across TCGA pan-cancer cohorts, TP53RK Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TP53RK data layer compared with 30 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TP53RK Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TP53RK expression acts as an unfavorable survival marker.

STAD, LUSC, and HNSC are the cancer types where TP53RK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.047	0.688	<.001	36	view →
LUSC	OS	Median	All	0.011	0.776	<.001	36	view →
HNSC	OS	Median	All	0.174	0.685	.022	18	view →
LIHC	DFS	Median	All	0.054	0.553	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TP53RK–STAD (OS)

Open the STAD breakdown →