TP53RK

Across TCGA pan-cancer cohorts, TP53RK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TP53RK data layer compared with 30 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TP53RK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TP53RK expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where TP53RK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.915	1.000	.031	24	view →
LUAD	DFS	Tertile	II,III,IV	0.769	0.917	.004	21	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	7	view →
LSCC	OS	Quartile	II,III,IV	0.921	0.447	.014	5	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TP53RK–COAD (DFS)

Open the COAD breakdown →