TP53I3

Across TCGA patient cohorts, TP53I3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,854 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TP53I3-associated genes across cancer lineages are SLC44A3-AS1, CASC15, and PTPN21. Each is linked with TP53I3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TP53I3-to-partner and partner-to-TP53I3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TP53I3 versus SLC44A3-AS1 in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53I3→partner) and Y-score (partner→TP53I3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC44A3-AS1 →	+0.547	+0.282	.001	.004	3	4
HNSC	CASC15 →	+0.996	+0.304	<.001	.002	3	4
BRCA	PTPN21 →	+0.526	+0.290	<.001	<.001	3	4
OV	ATAD2B →	+0.607	+0.628	.001	<.001	3	4
OV	RAB10 →	+0.429	+0.525	.003	.002	2	5
LSCC	ITGB6 →	+1.206	+0.325	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,854 associations by consensus.

TP53I3 vs SLC44A3-AS1 — HNSC

Explore this scatter interactively →