TP53I3

Across TCGA pan-cancer cohorts, TP53I3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TP53I3 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TP53I3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TP53I3 expression acts as an unfavorable survival marker, although some lineages such as ESCA and GBM show a favorable association.

ACC, SKCM, and LUAD are the cancer types where TP53I3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.443	0.801	<.001	108	view →
SKCM	DFS	Quartile	All	0.109	0.354	<.001	64	view →
LUAD	OS	Median	All	0.278	0.442	<.001	56	view →
LGG	OS	Median	All	0.725	0.893	<.001	54	view →
CESC	OS	Median	All	0.469	0.670	.005	38	view →
LIHC	DFS	Quartile	All	0.211	0.443	<.001	24	view →
BLCA	OS	Quartile	III,IV	0.450	0.727	.016	21	view →
ESCA	OS	Tertile	IV	0.674	0.143	.024	18	view →
GBM	OS	Tertile	All	0.579	0.259	.005	15	view →
READ	DFS	Median	II,III,IV	0.706	0.269	.021	10	view →
UCS	OS	Tertile	All	0.632	0.225	.010	10	view →
COAD	OS	Median	II,III,IV	0.849	0.711	.023	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TP53I3–ACC (OS)

Open the ACC breakdown →