TP53I3

Across TCGA patient cohorts, TP53I3 mutation is significantly associated with the RNA expression of many other genes, with 195 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53I3-associated genes across cancer lineages are MIR548H3, RNA5SP146, and RNA5SP175. Each is linked with TP53I3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53I3-to-partner and partner-to-TP53I3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548H3 grouped by TP53I3-low versus TP53I3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53I3→partner) and Y-score (partner→TP53I3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR548H3 →	+0.445	+3.077	<.001	.009	3	2
SKCM	RNA5SP146 →	+0.591	+6.867	<.001	<.001	3	2
KIRC	RNA5SP175 →	+0.252	+5.038	.001	.009	3	2
KIRC	RNA5SP519 →	+0.411	+5.509	<.001	.004	3	2
UCEC	RNU6-91P →	+0.573	+3.132	<.001	.003	3	1
UCEC	MIR6894 →	+0.573	+2.496	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

MIR548H3 by TP53I3 expression — UCEC

Explore this box plot interactively →