TP53I3

Across TCGA patient cohorts, TP53I3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53I3-associated genes across cancer lineages are ERK2, ASNS, and Caspase-8. Each is linked with TP53I3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53I3-to-partner and partner-to-TP53I3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TP53I3-low versus TP53I3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53I3→partner) and Y-score (partner→TP53I3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.270	+3.000	.015	.037	2	1
UCEC	ASNS →	+0.807	+3.000	<.001	.037	2	1
UCEC	Caspase-8 →	-0.335	-3.000	.021	.037	2	1
UCEC	4E-BP1 →	+0.479	+3.000	.002	.037	2	1
UCEC	Cyclin-B1 →	+0.769	+3.000	.017	.037	1	2
UCEC	P-Cadherin →	-0.194	-2.986	.020	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ERK2 by TP53I3 expression — UCEC

Explore this box plot interactively →