TP53I3

Across TCGA cell cohorts, TP53I3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,670 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TP53I3-associated GO terms across cancer lineages are Regulation of cell-substrate junction organization, Lysosome organization, and Lytic vacuole organization. Each is linked with TP53I3 in more than 8 cancer types. Because this analysis shows association rather than direction, both TP53I3-to-partner and partner-to-TP53I3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction organization grouped by TP53I3-low versus TP53I3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53I3→partner) and Y-score (partner→TP53I3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction organization →	+0.204	+2.582	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Lysosome organization →	+0.050	+1.387	.005	.004	2	9
UPPER_AERODIGESTIVE_TRACT	Lytic vacuole organization →	+0.050	+1.387	.005	.004	2	9
LUNG_NSCLC_LUSC	Reactive oxygen species biosynthetic process →	+0.173	+1.515	.002	.006	2	9
BONE	Synaptic vesicle recycling via endosome →	+0.137	+2.696	<.001	<.001	3	8
BONE	Vacuole organization →	+0.068	+3.087	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,670 associations by consensus.

Regulation of cell-substrate junction organization by TP53I3 expression — BONE

Explore this box plot interactively →