TP53BP1

Across TCGA pan-cancer cohorts, TP53BP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TP53BP1 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TP53BP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TP53BP1 expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

HNSC, GBM, and UCEC are the cancer types where TP53BP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.809	1.000	.022	10	view →
GBM	OS	Quartile	All	0.566	0.346	.012	9	view →
UCEC	DFS	Quartile	All	0.966	0.777	.028	6	view →
OV	DFS	Median	All	1.000	0.856	.035	4	view →
LUAD	OS	Median	All	0.871	0.597	.011	4	view →
CCRCC	DFS	Median	All	0.884	0.978	.017	3	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TP53BP1–HNSC (OS)

Open the HNSC breakdown →