TP53BP1

Across TCGA pan-cancer cohorts, TP53BP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TP53BP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TP53BP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TP53BP1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where TP53BP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TP53BP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.543	<.001	8	view →
COAD	All	All	+0.498	<.001	8	view →
LIHC	Female	II,III,IV	+0.995	<.001	7	view →
CHOL	Male	All	+2.554	<.001	5	view →
STAD	Male	II,III,IV	+0.905	.007	4	view →
THCA	Male	II,III,IV	−0.702	.015	4	view →
LUAD	All	All	+0.357	.002	4	view →
KIRP	Female	II,III,IV	+0.877	.022	3	view →
LUSC	All	All	+0.339	.003	3	view →
KIRC	Male	II,III,IV	−0.330	.036	2	view →
KICH	All	All	−0.419	.026	1	view →
BRCA	All	II,III,IV	+0.193	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TP53BP1–HNSC

Open the HNSC breakdown →