TP53BP1

Across TCGA patient cohorts, TP53BP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,567 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TP53BP1-associated proteins across cancer lineages are TP53BP1_S1114, TP53BP1_T1056, and TP53BP1_S1094. Each is linked with TP53BP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both TP53BP1-to-partner and partner-to-TP53BP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TP53BP1 versus TP53BP1_S1114 in PDAC, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP1→partner) and Y-score (partner→TP53BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TP53BP1_S1114 →	+0.403	+0.370	<.001	<.001	3	9
BRCA	TP53BP1_T1056 →	+0.739	+0.710	<.001	<.001	3	9
COAD	TP53BP1_S1094 →	+0.632	+0.753	<.001	<.001	3	8
BRCA	TP53BP1_S294 →	+0.472	+0.475	<.001	<.001	3	8
LSCC	TP53BP1_S500 →	+0.583	+0.513	<.001	<.001	3	7
BRCA	TP53BP1_S552 →	+0.646	+0.505	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,567 associations by consensus.

TP53BP1 vs TP53BP1_S1114 — PDAC

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