TP53BP1

Across TCGA patient cohorts, TP53BP1 mutation is significantly associated with the RNA expression of many other genes, with 3,590 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53BP1-associated genes across cancer lineages are CLDN5, RNA5SP435, and RNA5SP473. Each is linked with TP53BP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TP53BP1-to-partner and partner-to-TP53BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN5 grouped by TP53BP1-low versus TP53BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP1→partner) and Y-score (partner→TP53BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLDN5 →	-0.568	-2.159	.002	.002	3	4
READ	RNA5SP435 →	+0.875	+4.142	<.001	.004	3	3
UCEC	RNA5SP473 →	+0.459	+1.096	<.001	.008	3	3
CESC	MIR3659 →	+0.155	+2.514	.002	.009	3	3
UCEC	CCDC134 →	+0.361	+1.523	.001	<.001	3	3
UCEC	TRMU →	+0.358	+2.353	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,590 associations by consensus.

CLDN5 by TP53BP1 expression — UCEC

Explore this box plot interactively →