TP53BP1

Across TCGA patient cohorts, TP53BP1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53BP1-associated genes across cancer lineages are ATM, 4E-BP1, and GAPDH. Each is linked with TP53BP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TP53BP1-to-partner and partner-to-TP53BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TP53BP1-low versus TP53BP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP1→partner) and Y-score (partner→TP53BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.505	-2.313	.004	.035	3	4
COAD	4E-BP1 →	+0.253	+3.169	.010	.018	3	3
SKCM	GAPDH →	+0.501	+2.807	.009	.002	3	3
UCEC	MEK1 →	+0.306	+2.169	.004	.002	3	2
UCEC	PCNA →	+0.177	+1.906	.004	<.001	3	2
UCEC	PDCD4 →	-0.334	-1.807	.014	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by TP53BP1 expression — COAD

Explore this box plot interactively →