TP53BP1

Across TCGA cell cohorts, TP53BP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,629 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TP53BP1-associated GO terms across cancer lineages are Microtubule nucleation, Regulation of cilium assembly, and Microtubule polymerization. Each is linked with TP53BP1 in more than 18 cancer types. Because this analysis shows association rather than direction, both TP53BP1-to-partner and partner-to-TP53BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule nucleation grouped by TP53BP1-low versus TP53BP1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP1→partner) and Y-score (partner→TP53BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Microtubule nucleation →	+0.122	+0.919	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of cilium assembly →	+0.068	+1.253	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Microtubule polymerization →	+0.118	+0.908	<.001	.003	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.102	+1.090	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.102	+1.215	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of RNA splicing →	+0.105	+1.251	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,629 associations by consensus.

Microtubule nucleation by TP53BP1 expression — PANCREAS

Explore this box plot interactively →