TP53BP1

Across TCGA cell cohorts, TP53BP1 mutation is significantly associated with the RNA expression of many other genes, with 612 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TP53BP1-associated genes across cancer lineages are MSGN1, C1orf189, and RETN. Each is linked with TP53BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53BP1-to-partner and partner-to-TP53BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by TP53BP1-low versus TP53BP1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP1→partner) and Y-score (partner→TP53BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MSGN1 →	+0.192	+4.459	<.001	.001	3	2
SOFT_TISSUE	C1orf189 →	+0.212	+3.865	<.001	.006	3	2
STOMACH	RETN →	+0.054	+3.017	<.001	.001	3	2
BLOOD_Leukemia	HHLA1 →	+0.009	+3.966	<.001	.001	3	2
BLOOD_Leukemia	CBY2 →	+0.286	+3.544	<.001	.008	3	2
LARGE_INTESTINE	SARAF →	+0.622	+3.321	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 612 associations by consensus.

MSGN1 by TP53BP1 expression — SOFT_TISSUE

Explore this box plot interactively →