TP53AIP1

Across TCGA patient cohorts, TP53AIP1 mutation is significantly associated with the RNA expression of many other genes, with 655 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53AIP1-associated genes across cancer lineages are RPL23AP90, ELOCP27, and FAM149B1P1. Each is linked with TP53AIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53AIP1-to-partner and partner-to-TP53AIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP90 grouped by TP53AIP1-low versus TP53AIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53AIP1→partner) and Y-score (partner→TP53AIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP90 →	+0.354	+2.641	.005	.005	3	2
UCEC	ELOCP27 →	+0.424	+3.365	.005	<.001	3	2
SKCM	FAM149B1P1 →	+0.049	+3.819	.007	.009	3	2
UCEC	ATF4P1 →	+0.072	+3.454	<.001	<.001	3	2
UCEC	RPS29P32 →	+0.633	+2.792	<.001	.006	3	1
UCEC	MIR8071-2 →	+1.180	+2.906	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 655 associations by consensus.

RPL23AP90 by TP53AIP1 expression — UCEC

Explore this box plot interactively →