TP53

Across TCGA patient cohorts, TP53 protein abundance is significantly associated with the RNA expression of many other genes, with 4,714 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TP53-associated genes across cancer lineages are FAAP24, PIF1, and CDC25C. Each is linked with TP53 in more than 3 cancer types. Because this analysis shows association rather than direction, both TP53-to-partner and partner-to-TP53 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TP53 versus FAAP24 in OV, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53→partner) and Y-score (partner→TP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAAP24 →	+0.605	+0.799	.002	.007	3	3
BRCA	PIF1 →	+0.898	+0.866	<.001	.003	2	4
OV	CDC25C →	+0.741	+1.081	.001	<.001	3	3
COAD	R3HDML →	+1.122	+1.023	.006	.002	3	2
COAD	CDADC1 →	+0.308	+0.897	.004	.004	3	2
BRCA	NEURL1 →	-1.212	-0.760	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,714 associations by consensus.

TP53 vs FAAP24 — OV

Explore this scatter interactively →