TP53

Across TCGA pan-cancer cohorts, TP53 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TP53 data layer compared with 17 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TP53 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TP53 expression acts as an unfavorable survival marker, although some lineages such as STAD and CESC show a favorable association.

ACC, UCS, and MESO are the cancer types where TP53 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.130	0.744	<.001	61	view →
UCS	DFS	Quartile	II,III,IV	0.151	0.617	.001	56	view →
MESO	OS	Quartile	II,III,IV	0.384	0.663	.005	49	view →
STAD	DFS	Median	II,III,IV	0.487	0.265	.005	33	view →
LGG	OS	Median	All	0.752	0.870	<.001	31	view →
CESC	OS	Quartile	II,III,IV	0.918	0.626	.013	24	view →
BLCA	OS	Quartile	IV	0.349	0.657	<.001	22	view →
KIRC	DFS	Median	IV	0.632	0.280	.004	20	view →
UVM	DFS	Median	II,III,IV	0.597	0.893	.014	17	view →
READ	DFS	Median	III,IV	0.844	0.328	.025	11	view →
HNSC	OS	Tertile	All	0.246	0.519	.006	9	view →
CHOL	DFS	Median	All	0.765	0.117	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TP53–ACC (DFS)

Open the ACC breakdown →