TP53

Across TCGA patient cohorts, TP53 mutation is significantly associated with the RNA expression of many other genes, with 26,142 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TP53-associated genes across cancer lineages are SPATA18, AURKA, and OR7E38P. Each is linked with TP53 in more than 17 cancer types. Because this analysis shows association rather than direction, both TP53-to-partner and partner-to-TP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA18 grouped by TP53-low versus TP53-high in ACC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53→partner) and Y-score (partner→TP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	SPATA18 →	-1.845	-3.285	<.001	.006	3	18
UCEC	AURKA →	+0.927	+1.801	<.001	<.001	3	17
BRCA	OR7E38P →	+0.772	+1.821	<.001	<.001	3	17
SKCM	CDKN1A →	-1.764	-3.372	<.001	<.001	3	17
LIHC	SAMD4B →	+0.494	+1.447	<.001	<.001	3	17
LIHC	NSMCE2 →	+0.412	+0.933	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 26,142 associations by consensus.

SPATA18 by TP53 expression — ACC

Explore this box plot interactively →