TP53

Across TCGA cell cohorts, TP53 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,470 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TP53-associated GO terms across cancer lineages are Oxidative stress-induced premature senescence, Positive regulation of RNA polymerase II transcription preinitiation complex assembly, and Regulation of G1 to G0 transition. Each is linked with TP53 in more than 19 cancer types. Because this analysis shows association rather than direction, both TP53-to-partner and partner-to-TP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative stress-induced premature senescence grouped by TP53-low versus TP53-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53→partner) and Y-score (partner→TP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Oxidative stress-induced premature senescence →	+1.016	+2.229	<.001	<.001	3	20
LIVER	Positive regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.219	+2.410	<.001	<.001	3	20
LIVER	Regulation of G1 to G0 transition →	+0.225	+2.320	<.001	<.001	3	19
BONE	Regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.186	+3.136	<.001	<.001	3	18
BLOOD_Myeloma	Mitotic G1 DNA damage checkpoint signaling →	+0.165	+1.582	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Bone marrow development →	+0.280	+1.875	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,470 associations by consensus.

Oxidative stress-induced premature senescence by TP53 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →