TP53

Across TCGA cell cohorts, TP53 mutation is significantly associated with the RNA expression of many other genes, with 4,973 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TP53-associated genes across cancer lineages are CDKN1A, MDM2, and RPS27L. Each is linked with TP53 in more than 13 cancer types. Because this analysis shows association rather than direction, both TP53-to-partner and partner-to-TP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN1A grouped by TP53-low versus TP53-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53→partner) and Y-score (partner→TP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDKN1A →	-2.594	-1.455	<.001	<.001	3	14
SOFT_TISSUE	MDM2 →	-2.030	-2.458	<.001	<.001	3	14
URINARY_TRACT	RPS27L →	-1.449	-2.000	<.001	.002	3	13
BONE	ZMAT3 →	-1.217	-1.584	<.001	.002	3	12
BLOOD_Leukemia	PHLDA3 →	-2.019	-1.204	<.001	<.001	3	12
URINARY_TRACT	EDA2R →	-2.324	-2.169	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,973 associations by consensus.

CDKN1A by TP53 expression — BLOOD_Leukemia

Explore this box plot interactively →