Across TCGA patient cohorts, TOR4A mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOR4A-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with TOR4A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR4A-to-partner and partner-to-TOR4A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR4A→partner) and Y-score (partner→TOR4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.246	-2.000	.029	.032	3	1
UCEC	A-Raf_pS299 →	-0.175	-3.169	.001	.019	3	1
UCEC	ERK2 →	+0.240	+3.169	.005	.018	3	1
UCEC	JNK2 →	+0.341	+3.331	<.001	.005	3	1
UCEC	Ku80 →	+0.283	+2.713	.007	.003	3	1
UCEC	MEK1 →	+0.392	+2.459	.017	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

TOR4A survival (RNA) · tumor vs normal (RNA) · all TOR4A data types