Across TCGA cell cohorts, TOR4A mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOR4A-associated genes across cancer lineages are OR10W1, SAMD7, and TEX46. Each is linked with TOR4A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR4A-to-partner and partner-to-TOR4A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR4A→partner) and Y-score (partner→TOR4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
LARGE_INTESTINE	SAMD7 →	+0.013	+3.141	.003	.002	3	1
LARGE_INTESTINE	TEX46 →	+0.162	+3.497	<.001	.004	3	1
LARGE_INTESTINE	PTTG2 →	+0.069	+3.497	.005	.004	3	1
LARGE_INTESTINE	SFTPB →	+0.227	+3.770	<.001	.001	2	1
LARGE_INTESTINE	FAM205A →	+0.014	+3.029	.006	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

TOR4A survival (RNA) · tumor vs normal (RNA) · all TOR4A data types