TOR2A

Across TCGA patient cohorts, TOR2A mutation is significantly associated with the RNA expression of many other genes, with 473 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOR2A-associated genes across cancer lineages are RPL7P29, NUP35P1, and RNA5SP492. Each is linked with TOR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR2A-to-partner and partner-to-TOR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7P29 grouped by TOR2A-low versus TOR2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR2A→partner) and Y-score (partner→TOR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL7P29 →	+0.187	+4.478	.001	.005	3	2
CESC	NUP35P1 →	+0.060	+5.669	<.001	.003	3	2
UCEC	RNA5SP492 →	+0.268	+2.261	<.001	.007	3	2
BLCA	IGHVII-40-1 →	+1.050	+5.064	<.001	.001	3	1
BLCA	OR9L1P →	+0.042	+4.685	<.001	.007	3	1
BLCA	GIMAP1-GIMAP5 →	+0.036	+4.497	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 473 associations by consensus.

RPL7P29 by TOR2A expression — COAD

Explore this box plot interactively →