TOR2A

Across TCGA pan-cancer cohorts, TOR2A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TOR2A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TOR2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TOR2A is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where TOR2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOR2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.896	<.001	12	view →
KIRC	Female	All	+0.504	<.001	11	view →
LIHC	Female	II,III,IV	+0.976	<.001	9	view →
BLCA	All	All	+0.945	<.001	9	view →
KIRP	Male	II,III,IV	+0.731	<.001	8	view →
STAD	All	II,III,IV	+1.094	<.001	7	view →
BRCA	All	III,IV	+1.260	<.001	6	view →
UCEC	All	All	+0.733	<.001	6	view →
CHOL	All	All	+1.041	<.001	5	view →
THCA	Male	III,IV	−0.461	<.001	5	view →
ESCA	All	All	+1.066	<.001	3	view →
PRAD	All	All	+0.486	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TOR2A–HNSC

Open the HNSC breakdown →