TOR2A

Across TCGA cell cohorts, TOR2A mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOR2A-associated genes across cancer lineages are HMHB1, KRTAP11-1, and KRTAP19-8. Each is linked with TOR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR2A-to-partner and partner-to-TOR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMHB1 grouped by TOR2A-low versus TOR2A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR2A→partner) and Y-score (partner→TOR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HMHB1 →	+0.076	+6.022	<.001	.001	3	1
OVARY	KRTAP11-1 →	+0.139	+5.807	<.001	.001	3	1
OVARY	KRTAP19-8 →	+0.410	+5.807	<.001	.001	3	1
LUNG_NSCLC_LUAD	LCE1C →	+0.045	+4.887	.006	.009	3	1
BLOOD_Leukemia	SLC32A1 →	+0.457	+3.901	.009	.006	3	1
BLOOD_Leukemia	SLC28A1 →	+0.023	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

HMHB1 by TOR2A expression — SKIN

Explore this box plot interactively →