TOR1A

Across TCGA patient cohorts, TOR1A mutation is significantly associated with the RNA expression of many other genes, with 628 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOR1A-associated genes across cancer lineages are SNORD90, OR1D4, and MIR6853. Each is linked with TOR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR1A-to-partner and partner-to-TOR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD90 grouped by TOR1A-low versus TOR1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR1A→partner) and Y-score (partner→TOR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD90 →	+0.374	+2.518	<.001	.002	3	2
LUSC	OR1D4 →	+0.089	+4.466	<.001	.002	3	2
BRCA	MIR6853 →	+0.305	+8.057	<.001	.005	3	1
BLCA	RNU7-53P →	+0.778	+7.640	<.001	.009	3	1
UCEC	CCL5 →	+1.092	+2.828	.005	.001	3	1
UCEC	DOC2B →	-1.061	-2.807	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 628 associations by consensus.

SNORD90 by TOR1A expression — UCEC

Explore this box plot interactively →