TOR1A

Across TCGA pan-cancer cohorts, TOR1A RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TOR1A data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TOR1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOR1A expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

ACC, KIRC, and KIRP are the cancer types where TOR1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.162	0.729	<.001	107	view →
KIRC	DFS	Tertile	All	0.767	0.479	<.001	54	view →
KIRP	DFS	Quartile	All	0.868	0.979	.003	38	view →
HNSC	OS	Median	All	0.485	0.714	.003	34	view →
UVM	DFS	Quartile	II,III,IV	0.291	0.841	.002	33	view →
BLCA	DFS	Median	All	0.482	0.683	.006	32	view →
LGG	OS	Median	All	0.857	0.935	.001	23	view →
SCLC	DFS	Quartile	II,III,IV	0.831	0.474	.007	23	view →
THYM	DFS	Tertile	All	0.960	0.775	.003	18	view →
PAAD	OS	Quartile	All	0.681	0.426	.009	15	view →
SARC	OS	Median	All	0.850	0.602	<.001	13	view →
STAD	OS	Median	III,IV	0.349	0.647	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

TOR1A–ACC (DFS)

Open the ACC breakdown →