TOR1A

Across TCGA patient cohorts, TOR1A mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOR1A-associated genes across cancer lineages are ATM, Bak, and Caspase-7-cleavedD198. Each is linked with TOR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR1A-to-partner and partner-to-TOR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TOR1A-low versus TOR1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR1A→partner) and Y-score (partner→TOR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.747	-2.986	<.001	.035	3	2
UCEC	Bak →	+0.232	+3.169	.040	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.584	+3.341	.029	.005	3	2
UCEC	C-Raf →	+0.172	+2.321	.007	.034	3	2
UCEC	EGFR_pY1068 →	-0.342	-3.584	.002	.002	3	1
UCEC	EGFR →	-0.252	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by TOR1A expression — UCEC

Explore this box plot interactively →