Across TCGA patient cohorts, TOPORS mutation is significantly associated with the RNA expression of many other genes, with 4,122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOPORS-associated genes across cancer lineages are RN7SKP87, CSH2, and LCEP4. Each is linked with TOPORS in more than 1 cancer types. Because this analysis shows association rather than direction, both TOPORS-to-partner and partner-to-TOPORS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPORS→partner) and Y-score (partner→TOPORS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SKP87 →	+0.251	+4.445	<.001	.005	3	2
READ	CSH2 →	+0.023	+4.925	<.001	.004	3	2
KIRP	LCEP4 →	+0.097	+5.528	<.001	.002	3	2
CESC	IGHD4-4 →	+1.248	+3.839	<.001	.004	3	2
CESC	LINC01670 →	+0.083	+3.950	<.001	.003	3	2
LUSC	RBFA →	+0.446	+3.333	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,122 associations by consensus.

Exploration

TOPORS survival (RNA) · tumor vs normal (RNA) · all TOPORS data types