TOPAZ1

Across TCGA patient cohorts, TOPAZ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,755 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TOPAZ1-associated GO terms across cancer lineages are Modification of synaptic structure, Negative regulation of cell cycle G2/M phase transition, and Regulation of microtubule polymerization. Each is linked with TOPAZ1 in more than 9 cancer types. Because this analysis shows association rather than direction, both TOPAZ1-to-partner and partner-to-TOPAZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Modification of synaptic structure grouped by TOPAZ1-low versus TOPAZ1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPAZ1→partner) and Y-score (partner→TOPAZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Modification of synaptic structure →	+0.057	+0.098	<.001	<.001	3	10
STAD	Negative regulation of cell cycle G2/M phase transition →	+0.068	+0.087	<.001	<.001	3	10
ESCA	Regulation of microtubule polymerization →	+0.081	+0.149	<.001	.001	3	10
STAD	Protein-containing complex disassembly →	+0.068	+0.092	<.001	<.001	3	10
ESCA	Negative regulation of protein catabolic process →	+0.083	+0.181	<.001	.001	3	10
STAD	Regulation of mRNA splicing, via spliceosome →	+0.084	+0.091	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,755 associations by consensus.

Modification of synaptic structure by TOPAZ1 expression — STAD

Explore this box plot interactively →