TOPAZ1

Across TCGA patient cohorts, TOPAZ1 mutation is significantly associated with the RNA expression of many other genes, with 3,760 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOPAZ1-associated genes across cancer lineages are VN1R6P, RNA5SP412, and C16orf74. Each is linked with TOPAZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOPAZ1-to-partner and partner-to-TOPAZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R6P grouped by TOPAZ1-low versus TOPAZ1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPAZ1→partner) and Y-score (partner→TOPAZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	VN1R6P →	+0.036	+4.559	<.001	.006	3	2
UCEC	RNA5SP412 →	+0.463	+1.464	<.001	.002	3	2
UCEC	C16orf74 →	-0.551	-1.715	.005	.006	3	2
UCEC	GBP5 →	+0.936	+1.513	<.001	<.001	3	2
UCEC	PHYHIP →	-0.361	-2.300	.002	<.001	3	2
UCEC	CXCL10 →	+1.081	+2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,760 associations by consensus.

VN1R6P by TOPAZ1 expression — CESC

Explore this box plot interactively →