TOPAZ1

Across TCGA cell cohorts, TOPAZ1 mutation is significantly associated with the RNA expression of many other genes, with 209 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOPAZ1-associated genes across cancer lineages are ALKAL1, SNTG2, and SH3GL2. Each is linked with TOPAZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOPAZ1-to-partner and partner-to-TOPAZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALKAL1 grouped by TOPAZ1-low versus TOPAZ1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPAZ1→partner) and Y-score (partner→TOPAZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ALKAL1 →	+0.046	+3.285	.001	.009	3	2
OVARY	SNTG2 →	+0.233	+2.378	<.001	.009	3	2
LARGE_INTESTINE	SH3GL2 →	+0.891	+2.158	.003	.004	3	2
LARGE_INTESTINE	FITM1 →	+0.267	+3.339	<.001	.001	3	2
BLOOD_Myeloma	GABRA4 →	+0.914	+3.514	<.001	.008	3	1
PANCREAS	PRKACG →	+0.006	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 209 associations by consensus.

ALKAL1 by TOPAZ1 expression — BLOOD_Myeloma

Explore this box plot interactively →