Across TCGA patient cohorts, TOP3BP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,286 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TOP3BP1-associated GO terms across cancer lineages are Macromolecule methylation, Negative regulation of DNA-templated transcription, elongation, and Positive regulation of double-strand break repair. Each is linked with TOP3BP1 in more than 18 cancer types. Because this analysis shows association rather than direction, both TOP3BP1-to-partner and partner-to-TOP3BP1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3BP1→partner) and Y-score (partner→TOP3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Macromolecule methylation →	+0.045	+0.112	<.001	<.001	3	19
ESCA	Negative regulation of DNA-templated transcription, elongation →	+0.056	+0.130	.005	.003	2	19
STAD	Positive regulation of double-strand break repair →	+0.044	+0.123	<.001	<.001	3	18
ESCA	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.061	+0.137	.001	.001	3	17
STAD	Positive regulation of DNA repair →	+0.043	+0.121	<.001	<.001	3	17
STAD	Methylation →	+0.043	+0.126	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,286 associations by consensus.

Exploration

TOP3BP1 survival (RNA) · tumor vs normal (RNA) · all TOP3BP1 data types