Across TCGA pan-cancer cohorts, TOP3BP1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TOP3BP1 data layer.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TOP3BP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOP3BP1 expression acts as an unfavorable survival marker, although some lineages such as GBM and ESCA show a favorable association.
LIHC, CHOL, and GBM are the cancer types where TOP3BP1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.