TOP3B

Across TCGA patient cohorts, TOP3B mutation is significantly associated with the RNA expression of many other genes, with 4,355 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOP3B-associated genes across cancer lineages are RNA5SP417, LSM6P2, and RNA5SP432. Each is linked with TOP3B in more than 2 cancer types. Because this analysis shows association rather than direction, both TOP3B-to-partner and partner-to-TOP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP417 grouped by TOP3B-low versus TOP3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3B→partner) and Y-score (partner→TOP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP417 →	+0.303	+1.521	.001	.006	3	3
BRCA	LSM6P2 →	+0.186	+4.883	<.001	.006	3	2
LUAD	RNA5SP432 →	+0.293	+4.888	<.001	<.001	3	2
CESC	RNA5-8SP5 →	+0.195	+4.757	<.001	.004	3	2
CESC	MTND4LP20 →	+0.100	+5.579	<.001	.001	3	2
UCEC	GTSE1-DT →	+0.433	+1.642	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

RNA5SP417 by TOP3B expression — UCEC

Explore this box plot interactively →