TOP3B

Across TCGA cell cohorts, TOP3B mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOP3B-associated genes across cancer lineages are GSTT4, SPEM2, and BANF2. Each is linked with TOP3B in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP3B-to-partner and partner-to-TOP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTT4 grouped by TOP3B-low versus TOP3B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3B→partner) and Y-score (partner→TOP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSTT4 →	+0.156	+3.266	<.001	.003	3	2
LARGE_INTESTINE	SPEM2 →	+0.043	+3.989	.007	.001	3	2
OESOPHAGUS	BANF2 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A6E →	+0.050	+4.906	<.001	.006	3	1
OESOPHAGUS	MBD3L3 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	MBD3L4 →	+0.020	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

GSTT4 by TOP3B expression — BLOOD_Leukemia

Explore this box plot interactively →