TOP3A

Across TCGA patient cohorts, TOP3A mutation is significantly associated with the RNA expression of many other genes, with 4,425 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOP3A-associated genes across cancer lineages are TP53TG3GP, HROB, and UBL7. Each is linked with TOP3A in more than 2 cancer types. Because this analysis shows association rather than direction, both TOP3A-to-partner and partner-to-TOP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53TG3GP grouped by TOP3A-low versus TOP3A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3A→partner) and Y-score (partner→TOP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TP53TG3GP →	+0.433	+4.646	<.001	.008	3	3
UCEC	HROB →	+0.558	+1.828	<.001	<.001	3	3
SKCM	UBL7 →	+0.382	+3.208	.007	.009	3	3
UCEC	NCAPH2 →	+0.639	+2.321	<.001	<.001	3	3
SKCM	MCM2 →	+0.688	+3.350	.004	.005	3	3
UCEC	RN7SL134P →	+0.097	+2.014	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,425 associations by consensus.

TP53TG3GP by TOP3A expression — BRCA

Explore this box plot interactively →