Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts
Across TCGA patient cohorts, TOP1MT mutation is significantly associated with the RNA expression of many other genes, with 2,189 significant associations in total. UCEC shows the largest number of these associations.
The most reproducible TOP1MT-associated genes across cancer lineages are EIF4A1P2, MIR877, and MIR4305. Each is linked with TOP1MT in more than 2 cancer types. Because this analysis shows association rather than direction, both TOP1MT-to-partner and partner-to-TOP1MT results are reported.
Each partner links to its own Q-omics profile.
mutation associated genes by consensus
Ranked by combined sampling and lineage consensus. X-score (TOP1MT→partner) and Y-score (partner→TOP1MT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.