Across TCGA pan-cancer cohorts, TOP1MT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TOP1MT data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TOP1MT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TOP1MT expression acts as an unfavorable survival marker, although some lineages such as SCLC and THYM show a favorable association.

LIHC, ACC, and UCS are the cancer types where TOP1MT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Quartile	All	0.380	0.636	<.001	97	view →
ACC	DFS	Median	All	0.257	0.662	<.001	89	view →
UCS	DFS	Quartile	III,IV	0.267	0.566	.003	66	view →
KICH	OS	Quartile	II,III,IV	0.293	1.000	.002	62	view →
HNSC	DFS	Median	All	0.644	0.741	<.001	46	view →
KIRP	OS	Tertile	All	0.571	0.813	.003	38	view →
UVM	OS	Median	All	0.400	1.000	<.001	34	view →
UCEC	DFS	Median	All	0.797	0.877	.003	28	view →
PAAD	DFS	Quartile	All	0.217	0.442	.002	27	view →
THCA	DFS	Tertile	III,IV	0.570	0.880	.001	26	view →
MESO	OS	Median	All	0.306	0.466	.015	24	view →
LUSC	DFS	Quartile	III,IV	0.388	0.742	.009	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: TOP1MT tumor-vs-normal RNA expression · all TOP1MT data types