Across TCGA patient cohorts, TOP1MT mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOP1MT-associated genes across cancer lineages are ERK2, Ku80, and eEF2. Each is linked with TOP1MT in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP1MT-to-partner and partner-to-TOP1MT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP1MT→partner) and Y-score (partner→TOP1MT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.155	+1.847	.011	.007	3	2
UCEC	Ku80 →	+0.180	+2.013	.017	.016	3	2
UCEC	eEF2 →	+0.269	+1.289	.018	.023	3	1
UCEC	eIF4G →	+0.314	+3.087	.001	<.001	3	1
UCEC	ACVRL1 →	-0.096	-1.401	.027	.040	3	1
UCEC	MEK1 →	+0.341	+2.247	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

TOP1MT survival (RNA) · tumor vs normal (RNA) · all TOP1MT data types